Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer.

ABSTRACT:

Purpose

Lymphocytic infiltration of tumors predicts improved survival in patients with breast cancer. Previous studies have suggested that this survival benefit is confined predominantly to the basal-like subtype. Immune infiltration in ovarian tumors is also associated with improved prognosis. Currently, it is unclear what aspects of the immune response mediate this improved outcome.

Experimental design

Using The Cancer Genome Atlas mRNA-seq data and a large microarray dataset, we evaluated adaptive immune gene expression by genomic subtype in breast and ovarian cancer. To investigate B-cells observed to be prognostic within specific subtypes, we developed methods to analyze B-cell population diversity and degree of somatic hypermutation (SHM) from B-cell receptor (BCR) seq

SUBMITTER: Iglesia MD 

PROVIDER: S-EPMC4102637 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature