Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds.

ABSTRACT:

Background

The availability of high-density SNP assays including the BovineSNP50 (50 K) enables the identification of novel quantitative trait loci (QTL) and improvement of the resolution of the locations of previously mapped QTL. We performed a series of genome-wide association studies (GWAS) using 50 K genotypes scored in 18,274 animals from 10 US beef cattle breeds with observations for twelve body weights, calving ease and carcass traits.

Results

A total of 159 large-effects QTL (defined as 1-Mb genome windows explaining more than 1% of additive genetic variance) were identified. In general, more QTL were identified in analyses with bigger sample sizes. Four large-effect pleiotropic or closely linked QTLs located on BTA6 at 37-42 Mb (primarily at 38 Mb), on BTA7 at 93 Mb

SUBMITTER: Saatchi M 

PROVIDER: S-EPMC4102727 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature