HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development.

ABSTRACT: Aberrant activation of the HGF/MET signaling axis has been strongly implicated in the malignant transformation and progression of gastroesophageal cancer (GEC). MET receptor overexpression in tumor samples from GEC patients has been consistently correlated with an aggressive metastatic phenotype and poor prognosis. In preclinical GEC models, abrogation of HGF/MET signaling has been shown to induce tumor regression as well as inhibition of metastatic dissemination. Promising clinical results in patient subsets in which MET is overexpressed have spurned several randomized studies of HGF/MET-directed agents, including two pivotal global Phase III trials. Available data highlight the need for predictive biomarkers in order to select patients most likely to benefit from HGF/MET inhibition. In t

SUBMITTER: Hack SP 

PROVIDER: S-EPMC4102777 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature