The pro-apoptotic role of autophagy in breast cancer.

ABSTRACT:

Background

Autophagy is a catabolic process that has a vital role in cancer progression and treatment. Current chemotherapeutic agents, which target autophagy, result in growth inhibition in many cancer types. In this study, we examined the role of autophagy in breast cancer (BCa) patients as well as BCa cell lines.

Methods

Tissue microarray was used to detect the expression of an autophagy marker, LC3B in BCa patients (normal/hyperplasia=8; grade-I=15, grade-II=84, and grade-III=27) and BCa cell lines. To modulate the activation of autophagy, we used novel herbal compound nimocinol acetate (NA) in BCa cell lines and the anticancer activity was measured by phenotypic and molecular analysis.

Results

LC3B is highly expressed in tumours as compared with normal tissues. A

SUBMITTER: Suman S 

PROVIDER: S-EPMC4102935 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature