Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.

ABSTRACT:

Background

Hypopharyngeal squamous cell carcinoma (HSCC) has a very poor prognosis because of its high rates of regional and distant metastasis. Identification of differentially expressed miRNAs and their regulated molecular targets in tumour cells might enhance our understanding of the molecular mechanisms of metastasis in human cancers.

Methods

A HSCC miRNA signature was constructed by array-based methods. Functional studies of microRNA-451a (miR-451a) and target genes were performed to investigate cell proliferation, migration and invasion by cancer cell lines. To identify miR-451a-regulated molecular targets, we adopted gene expression analysis and in silico database analysis.

Results

Our miRNA signature revealed that miR-451a was significantly downregulated in HS

SUBMITTER: Fukumoto I 

PROVIDER: S-EPMC4102946 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature