Key roles for MYC, KIT and RET signaling in secondary angiosarcomas.

ABSTRACT:

Background

Angiosarcomas may develop as primary tumours of unknown cause or as secondary tumours, most commonly following radiotherapy to the involved field. The different causative agents may be linked to alternate tumorigenesis, which led us to investigate the genetic profiles of morphologically indistinguishable primary and secondary angiosarcomas.

Methods

Whole-genome (18k) c-DNA-mediated annealing, selection, extension and ligation analysis was used to genetically profile 26 primary and 29 secondary angiosarcomas. Key findings were thereafter validated using RT-qPCR, immunohistochemistry and validation of the gene signature to an external data set.

Results

In total, 103 genes were significantly deregulated between primary and secondary angiosarcomas. Secondary an

SUBMITTER: Styring E 

PROVIDER: S-EPMC4102954 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature