Efficacy of induction selection chemotherapy vs primary surgery for patients with advanced oral cavity carcinoma.

ABSTRACT:

Importance

The University of Michigan has investigated the use of induction selection (IS) with chemoradiotherapy (CRT) for patients who respond to CRT and found this approach effective in the management of advanced laryngeal cancer. The IS approach was extended to oral cavity squamous cell carcinoma (OCSCC) to help understand whether organ preservation or survival benefit resulted.

Objective

To evaluate the efficacy of an IS protocol vs primary surgical extirpation and selective postoperative radiotherapy for advanced OCSCC.

Design and setting

Retrospective matched cohort study at a tertiary care hospital.

Participants

Nineteen patients with resectable stages III and IV OCSCC were enrolled into a phase 2 IS trial. Patients with a response of at least 50% under

SUBMITTER: Chinn SB 

PROVIDER: S-EPMC4103099 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature