Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease.

ABSTRACT:

Background

Deep brain stimulation (DBS) is an effective and approved therapy for advanced Parkinson's disease (PD), and a recent study suggests efficacy in mid-stage disease. This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD.

Methods

Thirty subjects with idiopathic PD (Hoehn & Yahr Stage II off medication), age 50-75, on medication ≥6 months but ≤4 years, and without motor fluctuations or dyskinesias were randomized to optimal drug therapy (ODT) (n = 15) or DBS + ODT (n = 15). Co-primary endpoints were the time to reach a 4-point worsening from baseline in the UPDRS-III off therapy and the change in levodopa equivalent daily dose from baseline to 24 months.

Results

As hypothesized, the mean UPDRS

SUBMITTER: Charles D 

PROVIDER: S-EPMC4103427 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature