Mapping whole genome shotgun sequence and variant calling in mammalian species without their reference genomes.

ABSTRACT: Genomics research in mammals has produced reference genome sequences that are essential for identifying variation associated with disease.  High quality reference genome sequences are now available for humans, model species, and economically important agricultural animals.  Comparisons between these species have provided unique insights into mammalian gene function.  However, the number of species with reference genomes is small compared to those needed for studying molecular evolutionary relationships in the tree of life.  For example, among the even-toed ungulates there are approximately 300 species whose phylogenetic relationships have been calculated in the 10k trees project.  Only six of these have reference genomes:  cattle, swine, sheep, goat, water buffalo, and bison.  Although ref

SUBMITTER: Kalbfleisch T 

PROVIDER: S-EPMC4103496 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature