Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents.

ABSTRACT:

Background

Very few studies have been performed to understand the underlying neural substrates of adolescent major depressive disorder (MDD). Studies in depressed adults have demonstrated that the subgenual anterior cingulate cortex (sgACC) plays a pivotal role in depression and have revealed aberrant patterns of resting-state functional connectivity (RSFC). Here, we examine the RSFC of the sgACC in medication-naïve first-episode adolescents with MDD.

Methods

Twenty-three adolescents with MDD and 36 well-matched control subjects underwent functional magnetic resonance imaging to assess the RSFC of the sgACC.

Results

We observed elevated connectivity between the sgACC and the insula and between the sgACC and the amygdala in the MDD group compared with the control subje

SUBMITTER: Connolly CG 

PROVIDER: S-EPMC4103629 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature