Lower gastrointestinal tract cancer predisposition syndromes.

ABSTRACT: Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

SUBMITTER: Shah NB 

PROVIDER: S-EPMC4103645 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature