New advances in models and strategies for developing anti-obesity drugs.

ABSTRACT:

Introduction

Obesity is a worldwide pandemic. Obesity-related health and economic costs are staggering. Existing strategies to combat obesity through lifestyle improvements and medical intervention have had limited success. Pharmacotherapy, in combination with lifestyle modification, may play a vital role in reversing the disease burden. However, past and current weight-loss medications have had serious safety risks, notably cardiovascular and psychiatric events.

Areas covered

The authors review the strategies for designing new anti-obesity drugs by describing those currently in development. They describe their target, mechanism of action and developmental or regulatory status. Furthermore, they discuss the problem of weight regain following weight loss, and its relevance to

SUBMITTER: Kim GW 

PROVIDER: S-EPMC4103795 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature