The effect of vagal nerve blockade using electrical impulses on glucose metabolism in nondiabetic subjects.

ABSTRACT:

Purpose

Vagal interruption causes weight loss in humans and decreases endogenous glucose production in animals. However, it is unknown if this is due to a direct effect on glucose metabolism. We sought to determine if vagal blockade using electrical impulses alters glucose metabolism in humans.

Patients and methods

We utilized a randomized, cross-over study design where participants were studied after 2 weeks of activation or inactivation of vagal nerve blockade (VNB). Seven obese subjects with impaired fasting glucose previously enrolled in a long-term study to examine the effect of VNB on weight took part. We used a standardized triple-tracer mixed meal to enable measurement of the rate of meal appearance, endogenous glucose production, and glucose disappearance. The 550 k

SUBMITTER: Sathananthan M 

PROVIDER: S-EPMC4103924 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature