Vitamin D supplementation of breastfed infants: a randomized dose-response trial.

ABSTRACT:

Background

Breastfed infants require supplementation with vitamin D (vD), but little is known about the necessary dose. This double blind trial evaluated four different doses of vD.

Methods

Exclusively breastfed infants (N = 213) were randomized at 1 mo to one of four doses, which they received through 9 mo while receiving no formula. The supplements provided daily 200 IU, 400 IU, 600 IU, or 800 IU of vD. The primary endpoint was plasma 25(OH)D level, and secondary outcomes were plasma parathyroid hormone and calcium, and illness incidence. The study was conducted during winter at 41° N.

Results

Most infants had low (<50 nmol/l) 25(OH)D levels at 1 mo, but with supplementation levels rose. Overall, levels of 25(OH)D differed significantly in proportion to vD dose. The

SUBMITTER: Ziegler EE 

PROVIDER: S-EPMC4104134 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature