Rare copy number variation in treatment-resistant major depressive disorder.

ABSTRACT:

Background

While antidepressant treatment response appears to be partially heritable, no consistent genetic associations have been identified. Large, rare copy number variants (CNVs) play a role in other neuropsychiatric diseases, so we assessed their association with treatment-resistant depression (TRD).

Methods

We analyzed data from two genome-wide association studies comprising 1263 Caucasian patients with major depressive disorder. One was drawn from a large health system by applying natural language processing to electronic health records (i2b2 cohort). The second consisted of a multicenter study of sequential antidepressant treatments, Sequenced Treatment Alternatives to Relieve Depression. The Birdsuite package was used to identify rare deletions and duplications. Ind

SUBMITTER: O'Dushlaine C 

PROVIDER: S-EPMC4104153 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature