Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression.

ABSTRACT: Transcriptional enhancers integrate information derived from transcription factor binding to control gene expression. One key question concerns the extent of trans- and cis-regulatory variation in how co-expressed genes are controlled. The Drosophila CNS midline cells constitute a group of neurons and glia in which expression changes can be readily characterized during specification and differentiation. Using a transgenic approach, we compare the cis-regulation of multiple genes expressed in the Drosophila CNS midline primordium cells, and show that while the expression patterns may appear alike, the target genes are not equivalent in how these common expression patterns are achieved. Some genes utilize a single enhancer that promotes expression in all midline cells, while others utilize m

SUBMITTER: Pearson JC 

PROVIDER: S-EPMC4104230 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature