Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.

ABSTRACT:

Background

Clopidogrel is recommended after acute myocardial infarction but has variable efficacy and safety, in part related to the effect of cytochrome P450 (CYP) polymorphisms on its metabolism. The effect of CYP polymorphisms on cardiovascular events among clopidogrel-treated patients after acute myocardial infarction remains controversial, and no studies to date have investigated the association of CYP variants with outcomes in black patients.

Methods and results

Subjects (2732: 2062 whites; 670 blacks) hospitalized with acute myocardial infarction enrolled in the prospective, multicenter TRIUMPH study were genotyped for CYP polymorphisms. The majority of whites (79%) and blacks (64.4%) were discharged on clopidogrel. Among whites, carriers of the loss-of-function CYP2C

SUBMITTER: Cresci S 

PROVIDER: S-EPMC4104276 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature