Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.

ABSTRACT:

Purpose of review

This review analyzes recent studies suggesting that highly conserved epitopes in the HIV-1 Env trimer are targets of potentially protective nonneutralizing antibodies that mediate antibody-dependent cellular cytotoxicity.

Recent findings

Recent studies in both non-human primates and humans suggest that nonneutralizing antibodies play a role in blocking infection with hybrid simian HIV (SHIV)/simian immunodeficiency virus (SIV) or HIV-1 by Fc-mediated effector function, in particular antibody-dependent cellular cytotoxicity. Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies. However, these suggestions are controversial, as passive immunization studies do not indicate that such antibodies can

SUBMITTER: Lewis GK 

PROVIDER: S-EPMC4104495 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature