Modeling cell-cell interactions in regulating multiple myeloma initiating cell fate.

ABSTRACT: Cancer initiating cells have been documented in multiple myeloma and believed to be a key factor that initiates and drives tumor growth, differentiation,metastasis, and recurrence of the diseases. Although myeloma initiating cells (MICs) are likely to share many properties of normal stem cells, the underlying mechanisms regulating the fate of MICs are largely unknown. Studies designed to explore such communication are urgently needed to enhance our ability to predict the fate decisions of ICs (self-renewal, differentiation, and proliferation). In this study, we developed a novel system to understand the intercellular communication between MICs and their niche by seamlessly integrating experimental data and mathematical model. We first designed dynamic cell culture experiments and collected

SUBMITTER: Peng T 

PROVIDER: S-EPMC4104531 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature