The value of 18F-FDG PET/CT in recurrent gynecologic malignancies prior to pelvic exenteration.

ABSTRACT:

Objective

In patients undergoing pelvic exenteration for recurrent gynecological malignancies, we assessed the performance of [(18)F]-FDG PET/CT for delineating disease extent and evaluated the association between quantitative FDG uptake metrics (SUVmax, total lesion glycolysis [TLG] and metabolic tumor volume [MTV]) and progression-free survival (PFS) and overall survival (OS).

Methods

Retrospective study of patients undergoing pelvic exenteration for gynecologic malignancies between January 2002 and November 2011 who had FDG PET/CT within 90days before surgery. Two readers (R1, R2) independently determined the presence of bladder, rectum, vagina, cervix and pelvic side wall invasion and measured SUVmax, TLG and MTV in each patient. Areas under the curve (AUCs), for detecti

SUBMITTER: Burger IA 

PROVIDER: S-EPMC4104687 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature