A pooled analysis of waist circumference and mortality in 650,000 adults.

ABSTRACT:

Objectives

To assess the independent effect of waist circumference on mortality across the entire body mass index (BMI) range and to estimate the loss in life expectancy related to a higher waist circumference.

Patients and methods

We pooled data from 11 prospective cohort studies with 650,386 white adults aged 20 to 83 years and enrolled from January 1, 1986, through December 31, 2000. We used proportional hazards regression to estimate hazard ratios (HRs) and 95% CIs for the association of waist circumference with mortality.

Results

During a median follow-up of 9 years (maximum, 21 years), 78,268 participants died. After accounting for age, study, BMI, smoking status, alcohol consumption, and physical activity, a strong positive linear association of waist circumfer

SUBMITTER: Cerhan JR 

PROVIDER: S-EPMC4104704 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature