Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma.

ABSTRACT: Lymphomas are cancers that arise from white blood cells and usually present as solid tumors. Treatment of lymphoma often involves chemotherapy, and can also include radiotherapy and/or bone marrow transplantation. There is an un-questioned need for more effective therapies and diagnostic tool for lymphoma. Aptamers are single stranded DNA or RNA oligonucleotides whose three-dimensional structures are dictated by their sequences. The immense diversity in function and structure of nucleic acids enable numerous aptamers to be generated through an iterative in vitro selection technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). Aptamers have several biochemical properties that make them attractive tools for use as potential diagnostic and pharmacologic a

SUBMITTER: Shum KT 

PROVIDER: S-EPMC4104705 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature