Divergent and dynamic activity of endogenous retroviruses in burn patients and their inflammatory potential.

ABSTRACT: Genes constitute ~3% of the human genome, whereas human endogenous retroviruses (HERVs) represent ~8%. We examined post-burn HERV expression in patients' blood cells, and the inflammatory potentials of the burn-associated HERVs were evaluated. Buffy coat cells, collected at various time points from 11 patients, were screened for the expression of eight HERV families, and we identified their divergent expression profiles depending on patient, HERV, and time point. The population of expressed HERV sequences was patient-specific, suggesting HERVs' inherent genomic polymorphisms and/or differential expression potentials depending on characteristics of patients and courses of injury response. Some HERVs were shared among the patients, while the others were divergent. Interestingly, one burn-ass

SUBMITTER: Lee KH 

PROVIDER: S-EPMC4104748 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature