Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex.

ABSTRACT: Elucidating the genetic control of cerebral cortical (pallial) development is essential for understanding function, evolution, and disorders of the brain. Transcription factors (TFs) that embryonically regulate pallial regionalization are expressed in gradients, raising the question of how discrete domains are generated. We provide evidence that small enhancer elements active in protodomains integrate broad transcriptional information. CreER(T2) and GFP expression from 14 different enhancer elements in stable transgenic mice allowed us to define a comprehensive regional fate map of the pallium. We explored transcriptional mechanisms that control the activity of the enhancers using informatics, in vivo occupancy by TFs that regulate cortical patterning (CoupTFI, Pax6, and Pbx1), and analysi

SUBMITTER: Pattabiraman K 

PROVIDER: S-EPMC4104757 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature