Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens.

ABSTRACT: Prior research demonstrated that environmental enrichment creates individual differences in behavior leading to a protective addiction phenotype in rats. Understanding the mechanisms underlying this phenotype will guide selection of targets for much-needed novel pharmacotherapeutics. The current study investigates differences in proteome expression in the nucleus accumbens of enriched and isolated rats and the proteomic response to cocaine self-administration using a liquid chromatography mass spectrometry (LCMS) technique to quantify 1917 proteins. Results of complementary Ingenuity Pathways Analyses (IPA) and gene set enrichment analyses (GSEA), both performed using protein quantitative data, demonstrate that cocaine increases vesicular transporters for dopamine and glutamate as well as

SUBMITTER: Lichti CF 

PROVIDER: S-EPMC4104784 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature