An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.

ABSTRACT: PURPOSE:To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG). METHODS:After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0. RESULTS:Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ?4/?4 versus ?3/?3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ?2/?2 versus ?3/?3, ?2/?3 versus ?3/?3, ?2/?4 versus ?3/?3, ?3/?4 versus ?3/?3, allele ?2 versus allele ?3, and allele ?4 versus allele ?3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ?4/?4 versus ?3/?3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians. CONCLUSIONS:The present meta-analysis indicated that the ?4/?4 genotype is associated with increased risk of POAG in Asians.

SUBMITTER: Liao R 

PROVIDER: S-EPMC4105115 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature