An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.

ABSTRACT:

Purpose

To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).

Methods

After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.

Results

Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and alle

SUBMITTER: Liao R 

PROVIDER: S-EPMC4105115 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature