Temporal processing in schizophrenia: effects of task-difficulty on behavioral discrimination and neuronal responses.

ABSTRACT: Deficits in temporal judgment in schizophrenia have been observed in behavioral and electrophysiological studies for years. The functional neuroanatomy of temporal judgment in schizophrenia is, however, poorly understood. Recent neurophysiological research suggests that timing deficits in this population may not be widespread across all timing tasks, but specifically associated with high levels of difficulty. We evaluated differences between individuals with schizophrenia (N=16) and healthy subjects (N=18) during a temporal discrimination task at two levels of difficulty. Subjects were studied with functional magnetic resonance imaging (fMRI) at 3T while discriminating tone durations. Behaviorally, the schizophrenia group performed worse than the control group at both levels of difficulty.

SUBMITTER: Davalos DB 

PROVIDER: S-EPMC4105224 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature