Retinal architecture and mfERG: Optic nerve head component response characteristics in MS.

ABSTRACT:

Objective

To describe a novel neurophysiologic signature of the retinal ganglion cell and to elucidate its relationship to abnormalities in validated structural and functional measures of the visual system.

Methods

We used multifocal electroretinogram-generated optic nerve head component (ONHC) responses from normal subjects (n = 18), patients with multiple sclerosis (MS) (n = 18), and those with glaucoma (n = 3). We then characterized the relationship between ONHC response abnormalities and performance on low-contrast visual acuity, multifocal visual-evoked potential-induced cortical responses, and average and quadrant retinal nerve fiber layer (RNFL) thicknesses, as measured by spectral-domain optical coherence tomography.

Results

Compared with the eyes of normal su

SUBMITTER: Schnurman ZS 

PROVIDER: S-EPMC4105253 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature