Progranulin protein levels are differently regulated in plasma and CSF.

ABSTRACT:

Objective

We aimed to investigate the relationship between plasma and CSF progranulin (PGRN) levels.

Methods

Plasma and CSF PGRN were measured in a cohort of 345 subjects from the Mayo Clinic Study of Aging by ELISA. Single nucleotide polymorphism genotyping was performed using TaqMan assays. Associations between PGRN and sex, age at sample collection, diagnosis, single nucleotide polymorphism genotypes (GRN, SORT1, and APOE), and Pittsburgh compound B score were explored separately in CSF and plasma using single variable linear regression models. Pearson partial correlation coefficient was used to estimate the correlation of PGRN in CSF and plasma.

Results

Plasma (p = 0.0031) and CSF (p = 0.0044) PGRN significantly increased with age, whereas plasma PGRN levels were

SUBMITTER: Nicholson AM 

PROVIDER: S-EPMC4105255 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature