Initial cognitive decline is associated with cortical thinning in early Parkinson disease.

ABSTRACT:

Objectives

Our aim was to assess cortical thickness in a large multicenter cohort of drug-naive patients with early Parkinson disease (PD), with and without mild cognitive impairment (MCI), and explore the cognitive correlates of regional cortical thinning.

Methods

One hundred twenty-three newly diagnosed patients with PD and 56 healthy controls with 3-tesla structural MRI scans and complete neuropsychological assessment from the Parkinson's Progression Markers Initiative were included. Modified Movement Disorders Society Task Force level II criteria were applied to diagnose MCI in PD. FreeSurfer image processing and analysis software was used to measure cortical thickness across groups and the association with cognitive domains and tests.

Results

In patients with MCI

SUBMITTER: Pereira JB 

PROVIDER: S-EPMC4105257 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature