Strategic white matter tracts for processing speed deficits in age-related small vessel disease.

ABSTRACT:

Objective

Cerebral small vessel disease is the most common cause of vascular cognitive impairment and typically manifests with slowed processing speed. We investigated the impact of lesion location on processing speed in age-related small vessel disease.

Methods

A total of 584 community-dwelling elderly underwent brain MRI followed by segmentation of white matter hyperintensities. Processing speed was determined by the timed measure of the Trail Making Test part B. The impact of the location of white matter hyperintensities was assessed by voxel-based lesion-symptom mapping and graph-based statistical models on regional lesion volumes in major white matter tracts.

Results

Voxel-based lesion-symptom mapping identified multiple voxel clusters where the presence of white

SUBMITTER: Duering M 

PROVIDER: S-EPMC4105258 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature