Antemortem MRI findings associated with microinfarcts at autopsy.

ABSTRACT:

Objective

To determine antemortem MRI findings associated with microinfarcts at autopsy.

Methods

Patients with microinfarcts (n = 22) and patients without microinfarcts (n = 44) who underwent antemortem MRI were identified from a dementia clinic-based, population-based, and community clinic-based autopsy cohort. The microinfarct and no-microinfarct groups were matched on age at MRI, age at death, sex, APOE status, Mini-Mental State Examination score, and pathologic diagnosis of Alzheimer disease. Brain infarcts were assessed on fluid-attenuated inversion recovery (FLAIR) MRI. White matter hyperintensities on FLAIR MRI and hippocampal volumes on T1-weighted MRI were quantified using automated methods. A subset of subjects with microinfarcts (n = 15) and a matched group of sub

SUBMITTER: Raman MR 

PROVIDER: S-EPMC4105260 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature