Association of hypometabolism and amyloid levels in aging, normal subjects.

ABSTRACT:

Objective

We evaluated the relationship of amyloid, seen on Pittsburgh compound B (PiB)-PET, and metabolism, seen on [(18)F]-fluorodeoxyglucose (FDG)-PET, in normal subjects to better understand pathogenesis and biomarker selection in presymptomatic subjects.

Methods

Normal participants (aged 70-95 years; 600 with PiB-PET, FDG-PET, and MRI) were included. We performed a cross-sectional evaluation and subcategorized participants into amyloid-negative (<1.4), high-normal (1.4-1.5), positive (1.5-2.0), and markedly positive (>2.0) PiB standardized uptake value ratio groups representing different levels of amyloid brain load. Associations with metabolism were assessed in each group. Relationships with APOE ε4 carriage were evaluated.

Results

Hypometabolism in "Alzheimer d

SUBMITTER: Lowe VJ 

PROVIDER: S-EPMC4105262 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature