Clinical significance and association of RUNX3 hypermethylation frequency with colorectal cancer: a meta-analysis.

ABSTRACT:

Background

The RUNX family, which is composed of RUNX1, RUNX2, and RUNX3, is a sequence-specific transcription factor family and is closely involved in a variety of cellular processes including development, differentiation, participation in the regulation of p53-dependent DNA damage response and/or tumorigenesis. Emerging evidence indicates that RUNX3 is a candidate tumor suppressor in several types of human tumors including colorectal cancer (CRC). However, the correlation of RUNX3 inactivation with CRC remains unclear. In the study reported here, we conducted a systematic review and meta-analysis to quantitatively evaluate the effects of RUNX3 hypermethylation/expression on the incidence of CRC.

Methods

A detailed search of the literature was made using Medline(®) and Web

SUBMITTER: Mu WP 

PROVIDER: S-EPMC4105273 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature