Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats.

ABSTRACT:

Objective

The aim of this study was to obtain kinetic data that can be used in human risk assessment of titanium dioxide nanomaterials.

Methods

Tissue distribution and blood kinetics of various titanium dioxide nanoparticles (NM-100, NM-101, NM-102, NM-103, and NM-104), which differ with respect to primary particle size, crystalline form and hydrophobicity, were investigated in rats up to 90 days post-exposure after oral and intravenous administration of a single or five repeated doses.

Results

For the oral study, liver, spleen and mesenteric lymph nodes were selected as target tissues for titanium (Ti) analysis. Ti-levels in liver and spleen were above the detection limit only in some rats. Titanium could be detected at low levels in mesenteric lymph nodes. These res

SUBMITTER: Geraets L 

PROVIDER: S-EPMC4105399 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature