CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish population.

ABSTRACT:

Background and objective

There are inconsistent data of the cytochrome P450 1A1 (CYP1A1) Ile462Val (rs1048943) single nuclear polymorphism (SNP) as a genetic susceptibility factor for cervical cancer in various populations. Moreover, little is known about the interaction of this SNP with other risk factors, including contraceptive use, postmenopausal status, parity, and tobacco smoking.

Methods

Polymerase chain reaction-restriction fragment length polymorphism was used to study the prevalence of the CYP1A1 Ile462Val SNP in women with cervical cancer (n = 456) and controls (n = 495).

Results

Logistic regression analysis adjusting for age, parity, oral contraceptive use, tobacco smoking, and menopausal status demonstrated that that the CYP1A1 Ile/Val polymorphism was no

SUBMITTER: Roszak A 

PROVIDER: S-EPMC4105588 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature