Identification and characterisation of Aedes aegypti aldehyde dehydrogenases involved in pyrethroid metabolism.

ABSTRACT:

Background

Pyrethroid insecticides, especially permethrin and deltamethrin, have been used extensively worldwide for mosquito control. However, insecticide resistance can spread through a population very rapidly under strong selection pressure from insecticide use. The upregulation of aldehyde dehydrogenase (ALDH) has been reported upon pyrethroid treatment. In Aedes aegypti, the increase in ALDH activity against the hydrolytic product of pyrethroid has been observed in DDT/permethrin-resistant strains. The objective of this study was to identify the role of individual ALDHs involved in pyrethroid metabolism.

Methodology/principal findings

Three ALDHs were identified; two of these, ALDH9948 and ALDH14080, were upregulated in terms of both mRNA and protein levels in a DDT/pyr

SUBMITTER: Lumjuan N 

PROVIDER: S-EPMC4105619 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature