Serum amylase on the night of surgery predicts clinically significant pancreatic fistula after pancreaticoduodenectomy.

ABSTRACT:

Objectives

Drainage after pancreaticoduodenectomy (PD) remains controversial because the risk for uncontrolled postoperative pancreatic fistula (POPF) must be balanced against the potential morbidity associated with prolonged and possibly unnecessary drainage. This study investigated the utility of the level of serum amylase on the night of surgery [postoperative day (PoD) 0 serum amylase] to predict POPF.

Methods

A total of 185 patients who underwent PD were studied. Occurrences of POPF were graded using the International Study Group on Pancreatic Fistula (ISGPF) classification. Receiver operating characteristic (ROC) analysis identified a threshold value of PoD 0 serum amylase associated with clinically significant POPF (ISGPF Grades B and C) in a test cohort (n = 45). The

SUBMITTER: Palani Velu LK 

PROVIDER: S-EPMC4105898 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature