Getting pumped about heart failure.

ABSTRACT: Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.

SUBMITTER: Mann DL 

PROVIDER: S-EPMC4105985 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature