Antidepressant treatment response is modulated by genetic and environmental factors and their interactions.

ABSTRACT: Although there is a wide variety of antidepressants with different mechanisms of action available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a role in differences in medication response; however, available evidence is controversial. Even genome-wide association studies failed to identify genes or regions which would consequently influence treatment response. We conducted a literature review in order to uncover possible mechanisms concealing the direct effects of genetic variants, focusing mainly on reports from large-scale studies including STAR*D or GENDEP. We observed that inclusion of environmental factors, gene-environment and gene-gene interactions in the model improves the probability of identifying genetic modulator effects of antidepressant

SUBMITTER: Kovacs D 

PROVIDER: S-EPMC4106212 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature