Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice.

ABSTRACT:

Aims/hypothesis

Resistin was originally identified as an adipocyte-derived factor upregulated during obesity and as a contributor to obesity-associated insulin resistance. Clinically, resistin has also been implicated in cardiovascular disease in a number of different patient populations. Our aim was to simultaneously address these phenomena.

Methods

We generated mice with modest adipocyte-specific resistin overexpression. These mice were crossed with mice deficient in the LDL receptor (Ldlr (-/-)) to probe the physiological role of resistin. Both metabolic and atherosclerotic assessments were performed.

Results

Resistin overexpression led to increased atherosclerotic progression in Ldlr (-/-) mice. This was in part related to elevated serum triacylglycerol levels and

SUBMITTER: Asterholm IW 

PROVIDER: S-EPMC4106234 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature