Left middle frontal gyrus response to inhibitory errors in children prospectively predicts early problem substance use.

ABSTRACT:

Background

A core vulnerability trait for substance use disorder (SUD) is behavioral disinhibition. Error processing is a central aspect of inhibitory control that determines adaptive adjustment of performance; yet it is a largely overlooked aspect of disinhibition as it relates to risk for SUD. We investigated whether differences in brain activation during both successful and failed inhibition predicts early problem substance use.

Method

Forty-five 9-12 year olds underwent a functional MRI scan during a go/no-go task. They were then followed over approximately 4 years, completing assessments of substance use. Externalizing behavior was measured at ages 3-8, 9-12 and 11-13. Participants with drug use or problem alcohol use by ages 13-16 (n=13; problem-user group) were indivi

SUBMITTER: Heitzeg MM 

PROVIDER: S-EPMC4106478 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature