Microarray comparison of the gene expression profiles in the adult vs. embryonic day 14 rat liver.

ABSTRACT: The aim of the present study was to identify the differentially-expressed genes of embryonic day 14 (ED 14) rat liver in comparison to adult rat liver, which may provide specific information for the investigation of the hepatogenesis mechanism. The gene expression profiles of ED 14 and adult rat livers were investigated using microarray analysis (the Illumina RatRef-12 Expression BeadChip). Quantitative polymerase chain reaction (qPCR) analyses were conducted to confirm the gene expression. There were 787 genes upregulated in the embryonic liver. Based on the gene ontology classification system, which was analyzed by the database for annotation, visualization and integrated discovery software, a number of the upregulated genes were categorized into the distinct and differentially-expressed

SUBMITTER: Zheng J 

PROVIDER: S-EPMC4106633 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature