Cardiac function and tolerance to ischemia-reperfusion injury in chronic kidney disease.

ABSTRACT:

Background

Cardiac dysfunction is an independent risk factor of ischemic heart disease and mortality in chronic kidney disease (CKD) patients, yet the relationship between impaired cardiac function and tolerance to ischemia-reperfusion (IR) injury in experimental CKD remains unclear.

Methods

Cardiac function was assessed in 5/6 ablation-infarction (AI) and sham male Sprague-Dawley rats at 20 weeks of age, 8 weeks post-surgery using an isolated working heart system. This included measures taken during manipulation of preload and afterload to produce left ventricular (LV) function curves as well as during reperfusion following a 15-min ischemic bout. In addition, LV tissue was used for biochemical tissue analysis.

Results

Cardiac function was impaired in AI animals duri

SUBMITTER: Kuczmarski JM 

PROVIDER: S-EPMC4106638 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature