A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T).

ABSTRACT:

Objective

To determine the optimal infertility therapy for women at the end of their reproductive potential.

Design

Randomized clinical trial.

Setting

Academic medical centers and private infertility center in a state with mandated insurance coverage.

Patient(s)

Couples with ≥ 6 months of unexplained infertility; female partner aged 38-42 years.

Intervention(s)

Randomized to treatment with two cycles of clomiphene citrate (CC) and intrauterine insemination (IUI), follicle stimulating hormone (FSH)/IUI, or immediate IVF, followed by IVF if not pregnant.

Main outcome measure(s)

Proportion with a clinically recognized pregnancy, number of treatment cycles, and time to conception after two treatment cycles and at the end of treatment.

Result(s)

SUBMITTER: Goldman MB 

PROVIDER: S-EPMC4106674 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature