Insular and hippocampal gray matter volume reductions in patients with major depressive disorder.

ABSTRACT:

Background

Major depressive disorder is a serious psychiatric illness with a highly variable and heterogeneous clinical course. Due to the lack of consistent data from previous studies, the study of morphometric changes in major depressive disorder is still a major point of research requiring additional studies. The aim of the study presented here was to characterize and quantify regional gray matter abnormalities in a large sample of clinically well-characterized patients with major depressive disorder.

Methods

For this study one-hundred thirty two patients with major depressive disorder and 132 age- and gender-matched healthy control participants were included, 35 with their first episode and 97 with recurrent depression. To analyse gray matter abnormalities, voxel-based m

SUBMITTER: Stratmann M 

PROVIDER: S-EPMC4106847 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature