Genetic modifiers of cognitive maintenance among older adults.

ABSTRACT:

Objective

Identify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.

Methods

We conducted a genome-wide association study of ∼2.4 M markers to identify modifiers of cognitive trajectories in Caucasian participants (N = 7,328) from two population-based cohorts of non-demented elderly. Standardized measures of global cognitive function (z-scores) over 10 and 6 years were calculated among participants and mixed model regression was used to determine subject-specific cognitive slopes. "Cognitive maintenance" was defined as a change in slope of ≥ 0 and was compared with all cognitive decliners (slope < 0). In an independent cohort of cognitively normal older Caucasians

SUBMITTER: Yokoyama JS 

PROVIDER: S-EPMC4107001 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature