A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation.

ABSTRACT: Nerve conduction within the mammalian central nervous system is made efficient by oligodendrocyte-derived myelin. Historically, thyroid hormones have a well described role in regulating oligodendrocyte differentiation and myelination during development; however, it remains unclear which thyroid hormone receptors are required to drive these effects. This is a question with clinical relevance since nonspecific thyroid receptor stimulation can produce deleterious side-effects. Here we report that GC-1, a thyromimetic with selective thyroid receptor β action and a potentially limited side-effect profile, promotes in vitro oligodendrogenesis from both rodent and human oligodendrocyte progenitor cells. In addition, we used in vivo genetic fate tracing of oligodendrocyte progenitor cells via PDGF

SUBMITTER: Baxi EG 

PROVIDER: S-EPMC4107024 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature