Iron-responsive chromatin remodelling and MAPK signalling enhance adhesion in Candida albicans.

ABSTRACT: Recent cumulative data show that various transcription factors are recruited to the chromatin in an iron-responsive manner to affect diverse cellular functions in the pathogenic fungus Candida albicans. Here we identified groups of iron-responsive genes in C. albicans by chromatin remodelling analysis at gene promoters, using micrococcal nuclease (MNase) digestion followed by deep sequencing. Chromatin in the promoter regions of iron uptake and utilization genes showed repressed and active configuration, respectively, under iron-replete conditions. GO Term enrichment analysis of genes with differentially remodelled chromatin, in respective promoter locales, suggested that many genes involved in adhesion are also iron-responsive. C. albicans was observed to be more self-adherent (twofold in

SUBMITTER: Puri S 

PROVIDER: S-EPMC4107033 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature