Cerebellar networks in individuals at ultra high-risk of psychosis: impact on postural sway and symptom severity.

ABSTRACT: Despite known deficits in postural control in patients with schizophrenia, this domain has not been investigated in youth at ultra high-risk (UHR) for psychosis. This is particularly relevant as postural control implicates dysfunction in the cerebellum-a region implicated in cognitive dysmetria conceptions of schizophrenia but poorly understood in the prodrome. Here, we extended our understanding of movement abnormalities in UHR individuals to include postural control, and have linked these deficits to both symptom severity and cerebello-cortical network connectivity. UHR and healthy control participants completed an instrumentally based balance task to quantify postural control along with a resting state brain imaging scan to investigate cerebellar networks. We also quantified positive an

SUBMITTER: Bernard JA 

PROVIDER: S-EPMC4107098 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature